Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 1 Articles
Non steroidal anti-inflammatory drugs are not able to completely control the sequelae of inflammation. The purpose of this randomized, single blind study is to compare the efficacy of proteolytic enzymes such as serratiopeptidase, bromelian, trypsin-chymotrypsin as adjuncts with diclofenac on pre and post-operative swelling, pain and trismus after the removal of third molars. Eighty patients who underwent surgical removal of impacted third molar surgery were taken for study. The patients were divided into four groups. In the first group, each patient was given 100 mg of diclofenac sodium as control. In the second, third and fourth groups 5 mg of serratiopeptidase, 200 mg of bromelain, trypsin-chymotrypsin (106Armour units) were given respectively as adjuncts along with 100 mg of diclofenac sodium respectively. Parameters measured were cheek swelling, pain and trismus using measuring tape, visual analogue scale and calipers on the 1st, 2nd and 7th day pre and postoperatively. A proteolytic enzyme treatment as adjuncts was found to be better than diclofenac alone. Statistical analysis of the data indicated that on the 1st and 2nd days serratiopeptidase-diclofenac combination reduced the pain and swelling (P<0.001) when compared to the diclofenac group. Bromelain-diclofenac was found to be effective when compared to diclofenac (P<0.01), but provided less relief than serratiopeptidase. Trypsin-chymotrypsin group showed improvements, but not at a significant level. Compared to bromelain treatment, serratiopeptidase group was found to be more effective when given as adjunct with diclofenac. Serratiopeptidase could be a suitable adjunct to diclofenac in dental surgery....
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